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Tuesday, June 28, 2011

Fates of pyruvate (main aspects)

Lactic fermentation
- Main goal: to regenerate NAD+ through the reduction of pyruvate
- Subcellular localization: cytosol
- Conditions required to occur: anaerobic and/or absence of mitochondria
- Number of biochemical reactions: 1
- Energetic output (per pyruvate molecule): -1 NADH
- Final product (per pyruvate molecule): 1 lactate

Pyruvate oxidation
- Type of metabolic pathway: catabolic, linear
- Main goal: energy production from pyruvate oxidation
- Subcellular localization: mitochondrial matrix
- Conditions required to occur: aerobic
- Number of biochemical reactions: 1
- Energetic output (per pyruvate molecule): +1NADH
- Final product (per pyruvate molecule): 1 acetyl-CoA

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